Prognostic value of the immunohistochemical expression of: KI67, p53, pcna and bcl2 in the superficial tumors of the bladder

To study a serie of superficial tumors of the bladder and to assess the prognostic significance of p53, Ki67, PCNA and bc!2 in these tumors. We studied 59 bladder tumors: 43 pTa and 16 pTl. All Patients had cystoscopy 3 months after the resection and tumors that did not recur had a minimum follow up of 5 years. Age more than 65 years [p = 0,001], multifocality [p=0,022] and tumoral size > 3 cm [p = 0,022] were correlated with the recurrence. The expression of p53 was correlated with the recurrence in the year following the tumoral resection [p = 0,035]. That of of Ki67 was correlated with the histological grade [p = 0,03] and stage [p=0,002]. Our results suggest to practise regular endoscopic controls during the first year following the resection of the primitive tumor if it expresses p53. The immunohistochemical expression of Ki67 being correlated with the grade, this marker could help to better classify the tumors of intermediate grade

[Pelvic ganglioneuroma. Report of a case]

Ganglioneuroma is a rare benign tumor. It is the most mature of neurogenic tumors. We report a case of a pelvic ganglioneuroma diagnosed in 24-year-old pregnant women who presented with an urinary infection. Echographic examination suggested an ovarian mass. At surgical operation, the tumor was close to the sacrum. A total resection of the tumor was performed. Pathological examination proved it as a ganglioneuroma. Sixteen months later, the patient is free from disease

[Prognostic value of clinicopathologic factors in superficial bladder: a retrospective analysis of 59]

To study, through a series of superficial bladder tumors, the prognostic factors of recurrence and tumoral progression. this is a retrospective study of a series of 59 urothelial tumors of the bladder at stage pTa or pTl. The following parameters were considered: age, sex, treatment, stage and grade. The chi square test was used in search of a correlation between the different parameters and the course [recurrence and progress] of the disease. A multivariate analysis was undertaken by integrating factors correlated with the course. Thirty two tumors [54%] had recurred versus 27 [46%] without recurrence. Light tumors [25%] progressed in grade and 4 [12,5%] had become infiltrative. Age beyond 65 years. tumoral size > 3 cm and rnultifocality were predictive factors of recurrence with a relative risks of 2.36, 3,28 and 3,88 respectively. In a multivariate analysis, these factors remained significant with adjusted relative risks respectively of 1,36, 1,6 and 1,7

[ particular hepatocellular carcinoma combining the ordinary and the fibrolamellar variant]

Fibrolamellar carcinoma [FLC] of the liver is a rare variant of hepatocellular carcinoma [HCC] occurring on non cirrhotic liver. Since its first description by Hugh Edmondson in 1956, 200 cases of FLC have been reported in the literature, but only some cases describe the association of the ordinary HCC with the FLC within the same lesion. We report in this study the case of a 14-year-Old female patient with a hepatic mass whose radiological aspect evoked a nodular and focal hyperplasia. Histologically, this tumor was composed of area of FLC mixed with ordinary HCC. Staining for cytokeratine 7 was positive in the FL component and negative in the ordinary HCC component

Psoriasis pustuleux juvenile. A propos de 15 cas

Psoriasis is a common, chronic and recurrent inflammatory disease of the skin. Children were affected in 30% of cases. Severe form can be observed: pustular psoriasis [pp], psoriatic arthropathy and erythrodermic psoriasis. There were 15 children with an age range of 1-15.5 years, [mean age 7.56 years]. Psoriasis constituted 5% of the total dermatological disorders in children. The severe forms of psoriasis were rare in children annular pp was the most common form of pp in children. Juvenile pp had generally better prognostic than in adults, but the evolution is characterized by recurrences